Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 23، Issue: 1
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-23-1_006
تاریخ نمایه سازی: 4 آذر 1398
Abstract:
Objective(s): Zinc is an effective factor in the reproductive system. Insulin resistance (IR) is known as an important disorder in patients with polycystic ovary syndrome (PCOS). Mammalian target of rapamycin (mTOR), which controls key cell activities, in particular, is activated in disorders such as PCOS. The present study was conducted to observe the therapeutic effects of organic zinc on IR, mTOR gene expression, and pathogenesis of PCOS in a rat model induced-PCOS. Materials and Methods: Experimental treatments were performed on control and treated groups, consisting of healthy controls (Control, water, and standard feed intake and daily injection of sesame oil alone), Polycystic control (PCO, injection of 4 mg/kg estradiol valerate (EV) for four weeks). Treated groups (PCO-ZM 25, PCO-ZM 75, and PCO-ZM 175) after 4 weeks of receiving EV, were daily given three levels of 25, 75, and 175 mg zinc methionine/kg BW for 15 days, respectively.Results: Injection of EV dramatically increased body and ovarian weights, levels of LH, testosterone, estradiol, triglyceride, fasting insulin, fasting glucose, HOMA-IR, IGF-1, gene expression of mTOR, and number of cysts (P<0.05). It also reduced the level of progesterone, HDL-C, and the number of antral follicles (P<0.05). However, by increasing zinc-methionine application especially at 175 mg/kg BW, the induction effects of EV were improved on ovarian cysts (P<0.05). Conclusion: Organic zinc showed beneficial effects in the EV induced PCOS rats via decreased insulin resistance and mTOR expression, restored the hormonal profile, and decreased the number of cysts in the ovaries.
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Authors
Faeze Fazel Torshizi
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Mohammad Chamani
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Hamid Reza Khodaei
Department of Animal Sciences, Islamic Azad University, Golpayegan Branch, Isfahan, Iran
Ali Asghar Sadeghi
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
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