Preventive and therapeutic effects of tranexamic acid on postpartum bleeding
Publish place: Reviews in Clinical Medicine، Vol: 2، Issue: 1
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RCM-2-1_009
تاریخ نمایه سازی: 2 دی 1398
Abstract:
Postpartum hemorrhage is among the leading causes of maternal mortality throughout the world. Severe blood loss contributes to the increased blood transfusion risk with its concerned inherent adverse events and therefore increased rate of emergency re-operative interventions such as arterial ligation or hysterectomy. It also can lead to protracted anemia, particularly in low or median income countries. Extended application of antifibrinolytic agents such as tranexamic acid has been customary for long years to stop or reduce blood loss in postpartum period. However, there are not enough reliable evidence to approve the real efficacy of these drugs. In this brief and summary review, we pointed to a few conducted studies. The PubMed was searched for keyword including postpartum hemorrhage, tranexamic acid, cesarean section, vaginal delivery, and blood loss prevention. The articles with language other than English were excluded from our review. We concluded that more convincing information is needed to determine the precise effects of tranexamic acid, and its benefits against adverse effects.
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Authors
Samaneh Solltani
Department of Gynecology & Obstetric, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Masoumeh Mirteimouri
Department of Gynecology & Obstetric, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ameneh Movahedian
Department of Gynecology & Obstetric, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Nushin Chalakinia
Department of Gynecology & Obstetric, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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