Down-regulation of CYP27B1 gene expression in Iranian patients with relapsing-remitting multiple sclerosis
Publish place: The Third International and 15th National Genetics Congress
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CIGS15_593
تاریخ نمایه سازی: 13 بهمن 1398
Abstract:
BACKGROUND: Multiple sclerosis (MS) as a complex neurological disease can be due to vitamin D deficiency. CYP27B1 is referred to as a vitamin D metabolizing enzyme.MATERIALS AND METHODS: This study compared the expression level of CYP27B1 in Relapsing-Remitting MS (RRMS)patients with normal individuals in Iran. The RNA was extracted from 50 RRMS patients and 50 normal controls. Quantitative RT-PCR was adopted to measure the expression level of CYP27B1 gene. RESULTS: The expression level of CYP27B1gene was significantly lower in the RRMS patients than their normal counterparts (P value = 0.04). Also, the RRMS females participating had a significant reduction in CYP27B1 gene expression compared to normal females (P-Value = 0.01). In addition, the correlation between CYP27B1 expression level, and the risk of Expanded Disability Status Scale of Kurtzke (EDSS) was not linear. Additionally, there was no significant correlation between expression status of CYP27B1gene and duration of the disease. CONCLUSION: A significant decrease in the expression level of CYP27A1 in female patients could indicate their greater vulnerability to MS than the male patients.
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Authors
Zahra Rezaie
Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Mohammad Taheri
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran,Iran.Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Shahid Labbafi NejadEducational Hospital, Tehran, Iran
Leila Kohan
Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Arezou Sayad
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran,Iran