Role of Dopamine Receptors Expression in the cell cycle of cancer cells

Dopamine (DA) is the predominant catecholamine neuro-transmitter in the human central nervous system that has an important role in the renal, hormonal and central nervous systems. DA exerts its functions via binding to dopamine receptors (DRs). The alterations in the expression of five different dopamine receptor genes (DRD1- DRD5) associated with certain diseases of the immune and nervous systems have previously been reported, and play multiple roles in variousdisorders such as cancer. Lung cancer is the most common cancer in the world. Recent studies have provided new evidence that the dopaminergic pathway may be of interest in assessing risk of lung cancer. Moreover it has been considered that how expression of dopamine receptors could relate to apoptosis. In this review article, we will summarize current researches and knowledge inthis field and discuss possible strategies for the treatment of lung cancer such as using agonists of Dopamine receptors

Keywords:

Dopamine , Dopamine Receptors , Lung Cancer , Agonists