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Association between miR-34b/c rs4938723 and the recurrence risk in patients with breast cancer

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Year: 2018
COI code: CIGS15_021
Paper Language: English

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Authors Association between miR-34b/c rs4938723 and the recurrence risk in patients with breast cancer

  Elham Ghanbarpanah - Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
  Leila Kohan - Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
  Mohammad Mohammadianpanah - Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  Sedigheh Tahmasebi - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract:

Introduction & Aim: The recurrence of breast cancer (BC) is a major cause of cancer death in females. Mir-34b/c negatively regulates many cancers, by P53 gene targeting. The aim of our study was to examine association of the miR-34b/c rs4938723, with the recurrence of BC.Methods: The present study was done on 424 females with BC (102 patients with the recurrence of BC, as the case group, and 322 women without any recurrence of BC, as the control group). After DNA extraction from peripheral blood, genotype determination was done using Tetra ARMS PCR Technique. Thereafter, the genotype and allele frequency of miR-34b/c rs4938723 was compared between the two groups. Results: The results were shown that TC (OR=3.777; P=0.001) and CC (OR=7.094; P=0.001) genotypes and C (OR=2.605; P=0.001) allele of miR-34b/c rs4938723 are associated with BC recurrence. Conclusion: Thus, miR-34b/c rs4938723 polymorphism is associated with the susceptibility of BC recurrence.

Keywords:

Breast Cancer Recurrence, miR-34b/c, Polymorphism, micro RNA

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COI code: CIGS15_021

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Ghanbarpanah, Elham; Leila Kohan; Mohammad Mohammadianpanah & Sedigheh Tahmasebi, 2018, Association between miR-34b/c rs4938723 and the recurrence risk in patients with breast cancer, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_021.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Ghanbarpanah, Elham; Leila Kohan; Mohammad Mohammadianpanah & Sedigheh Tahmasebi, 2018)
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The University/Research Center Information:
Type: Azad University
Paper No.: 906
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