CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings
Paper
title

Long noncoding RNA,ANCR, is upregulated in esophageal squamous cell carcinoma

Credit to Download: 0 | Page Numbers 1 | Abstract Views: 58
Year: 2018
COI code: CIGS15_618
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors Long noncoding RNA,ANCR, is upregulated in esophageal squamous cell carcinoma

  Baharak Balalaei - Department of Molecular Genetics,Faculty of Biological Sciences,Tarbiat Modares University,Tehran, Iran
  Mahshid Malakootian - Cardiogenetic research lab, Rajaie Cardiovascular Medical and Research Center,Iran University of Medical Sciences,Tehran, Iran
  Reza Sahebi - Department of Molecular Genetics,Faculty of Biological Sciences,Tarbiat Modares University,Tehran, Iran
  Abdolvahab Moradi - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences,Gorgan, Iran
  Mohammad vasei - Tehran University of Medical Sciences,Tehran, Iran
  Seyed Javad Mowla - Department of Molecular Genetics,Faculty of Biological Sciences,Tarbiat Modares University,Tehran, Iran

Abstract:

Long noncoding RNAs(lncRNAs) are a major class of RNA molecules with emerging roles in stem cell pluripotency, cellular reprogramming, cellular transformation, and tumorigenesis. Anti-differentiation non-coding RNA, ANCR, is suppressed upon terminal differentiation of multiple cell types. The broad expression pattern of ANCR, in combination with its reduced expression levels in a number of terminally differentiated cell types raised the possibility of a potential functional role for ANCR in the tumorigenesis.At the present study, To identify a potential expression alteration of ANCR during tumorigenesis, we initially have examined the expression pattern of lncRNA-ANCR in esophageal squamous cell carcinoma (ESCC). The quantitative real-time RT-PCR results revealed a significant upregulation of ANCR(P value= 0.0161) in tumor samples of ESCC and in high-grade tumor samples, in comparison to the low-grade ones (P value= 0.0371). Moreover, the presense of amplified fragment of ANCR was detected in serum samples and we found a significant up-regulation of ANCR in serum samples with ESCC compared to normal samples(P value= 0.0392). Furthermore, Based on the results of sequencing،We found two variants of ANCR in ESCC samples and KYSE-30 cells. In conclusion, our data suggest a possible role of ANCR in tumorigenesis of esophageal tissues and demonstrate the expression different variants of ANCR in ESCC samples.

Keywords:

esophageal squamous cell carcinoma, non-coding RNA, lncRNA-ANCR, variants

Perma Link

https://www.civilica.com/Paper-CIGS15-CIGS15_618.html
COI code: CIGS15_618

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Balalaei, Baharak; Mahshid Malakootian; Reza Sahebi; Abdolvahab Moradi; Mohammad vasei & Seyed Javad Mowla, 2018, Long noncoding RNA,ANCR, is upregulated in esophageal squamous cell carcinoma, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_618.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Balalaei, Baharak; Mahshid Malakootian; Reza Sahebi; Abdolvahab Moradi; Mohammad vasei & Seyed Javad Mowla, 2018)
Second and more: (Balalaei; Malakootian; Sahebi; Moradi; vasei & Mowla, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)

Scientometrics

The University/Research Center Information:
Type: state university
Paper No.: 25985
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper

WHAT IS COI?

COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.