Investigation the effect of deuterium depleted water and 5-fluorouracil compound on enzymes activity in prostate cancer cell lines
Publish place: Second International Congress of Science and Engineering
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
GERMANCONF02_024
تاریخ نمایه سازی: 3 تیر 1398
Abstract:
Prostate cancer is a biologically heterogeneous disease which has become the fifth leading cause of death from cancer in men worldwide. In recent studies, deuterium-depleted water (DDW) therapy has been increasing. Also, studies have shown that 5-Fluorouracil (5-FU) has an anti-cancer effect. Therefore, the aim of this study was to investigate the effect of DDW and 5-FU on the enzyme activity in LN-CAP cell line. The activity of Catalase (CAT) and Malonyl dialdehyde (MDA) enzymes influenced by DDW and 5-FU in different concentrations on the LN-CAP cell line was investigated by the colorimetric method. Statistical analyses were performed with one-way analysis of variance (ANOVA) followed by t-Test. The result of this study showed that in cells treated with the different concentrations of DDW and 5-FU lead to the increase antioxidant activity of the cells.
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Authors
Amir Eshaghiyan
Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz,Iran.
Farzaneh Emadi
Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz,Iran.
Mosayeb Eghbali
Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz,Iran.
Fahimeh Nasimsobhan
Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar,Yazd, Iran.