Published in: First Personal Medical Congress
COI code: IPMCMED01_088
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors Genetic variants at 5p12 ( rs4415084 T/C and rs10941679 A/G ) and risk of breast cancer in Persian womenHamidreza Agha Heydarali Naghash - Karaj Branch, Islamic Azad University,Karaj,Iran
Ali Salehzadeh - Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran
Bahareh Abbasi - National Institute of Genetic Engineering and Biotechnology (NIGEB),Tehran,Iran
Nafiseh Ansarinejad - Iran University of Medical Sciences, Tehran,Iran
Abstract:Breast cancer (BC) is one of the most commonly occurring epithelial malignancies in women, with an estimated 1 million new cases and over 400,000 deaths annually worldwide. Despitemuch investigation, the causes are not yet fully understood. Accumulated evidence suggests that multiple genetic and environmental factors, as well as the interplay between these factors,determine the phenotype.Single nucleotide polymorphisms (SNPs) lead to genetic differences in breast cancer (BC) susceptibility among women from different ethnicities. The present study aimed at investigating the involvement of SNPs at chromosome 5p12.A genome-wide association study, conducted among women of European ancestry, has identified two single-nucleotide polymorphisms (SNPs) rs4415084 (T/C) and rs10941679 (A/G) at chromosome 5p12 were associated with risk of breast cancer, suggesting that genetic variants in this region may have a role in the development of breast cancer.The single nucleotide polymorphism 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease.Another study direct by Thomas et al.9 confirmed the single-nucleotide polymorphism.(SNP) rs4415084 might affect breast cancer risk in the European population. Both rs4415084 and rs10941679 conferred significantly greater risks of ER-positive breast cancer than of ER-negative tumors.The biological mechanism through which genetic variations in 5p12 influences BC risk remains unclear. To investigate the associations between SNPs at 5p12 and risk of breast cancer in the Persian women, we will conduct in 5p12 polymorphisms (rs4415084 and rs10941679) using a genotype these SNPs with a case–control study in the Iranian population.
Keywords:Breast cancer ,5p12,SNP,genetic variations
COI code: IPMCMED01_088
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Agha Heydarali Naghash, Hamidreza; Ali Salehzadeh; Bahareh Abbasi & Nafiseh Ansarinejad, 2016, Genetic variants at 5p12 ( rs4415084 T/C and rs10941679 A/G ) and risk of breast cancer in Persian women, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_088.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Agha Heydarali Naghash, Hamidreza; Ali Salehzadeh; Bahareh Abbasi & Nafiseh Ansarinejad, 2016)
Second and more: (Agha Heydarali Naghash; Salehzadeh; Abbasi & Ansarinejad, 2016)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: Azad University
Paper No.: 7144
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Environmental and Personal Factors Associated with Addiction Relapse in Referral Patients to Marand Treatment Centers
- The Effect of Implementation of an Elderly Respect Training Program in Families on Elder Abuse in Yazd
- Metabolic Syndrome and 10-Year Cardiovascular Diseases Risk among Male Taxi drivers in 2016: A Cross-Sectional Study in Yazd, Iran
- Investigating Risk Factors of Low-Birth-Weight among Mothers visiting Community Health Centers in the City of Yazd
- Socioeconomic Status and Osteoporosis Risk: A Case-control Study in Outpatient Women in Yazd
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.