Three-component reaction between Indole with Arylglyoxals and amidines
Publish place: 20th Iranian Chemical Congress
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IRANCC20_332
تاریخ نمایه سازی: 28 اردیبهشت 1398
Abstract:
Indole is among the most important chemical skeletons existing as the main core in the structure of diverse pharmaceutically important compounds. For example indole derivatives involve beneficial estron metabolism promoter [1], inhibitor for human prostate cancer cells and radical scavengers. The primary antitumor screening essay showed that some indole derivatives exhibited the inhibitory activities to some tumor cell growth at relatively high concentration [2, 3]. In this project we report a new and highly efficient method for synthesis of imidazolyl indole derivatives 4 by reaction between indole 1 with arylglyoxals 2 and amidine derivatives 3 in acetonitrile at room temperature in the presence of FeBr3 as a catalyst. The compound 4 can exist in equilibrium with compound 5.
Authors
Mohammad Reza Shahbazi-Manshadi
Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Mohammad Anary-Abbasinejad
Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Mozhgan Masoudi
Young Researchers and Elite Club, Rafsanjan Branch, Islamic Azad University, Rafsanjan, Iran