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Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus

Credit to Download: 1 | Page Numbers 16 | Abstract Views: 104
Year: 2019
COI code: JR_AJP-9-3_004
Paper Language: English

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Authors Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus

Karim Raafat - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, Lebanon
  Mohammad Mehdi Heidari - Department of Biology, Faculty of Science, Yazd University, Yazd, Iran
  Mehri Khatami - Department of Biology, Faculty of Science, Yazd University, Yazd, Iran
  Vahideh Ghorani - Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

Objective: Acanthus syriacus (AS) is one of the valuable herbal plants with immunomodulatory potentials. The aim of this study is to assemble a phytochemical investigation of A. syriacus exploring its anti-inflammatory and antinociceptive properties, identification of its most active compound(s) and elucidating their structure and determining their mechanisms of action. Materials and Methods: Bio-guided fractionation and isolation-schemes were used utilizing RP-HPLC, CC, 1H- and 13C-NMR, and biological-models were used to evaluate their effects against inflammation and neuropathic-pain (NP). Results: The outcomes showed that the most active fraction (FKCA) of AS was identified. Two of the three components of FKCA were identified by chromatographic-methods, while the third compound was isolated, its structure was elucidated and its was named Kromeic acid (KRA); FKCA contained Ferulic acid (27.5%), kromeic acid (48.1%), and chlorogenic acid (24.4%). AS, FKCA and KRA showed significant (p˂0.05) anti-inflammatory and antinociceptive potentials in the management of allodynia and thermal-hyperalgesia in NP. AS and FCKA showed comparatively equipotent antinociceptive-effects. FKCA showed higher antinociceptive effects than KRA suggesting additive-effects among FKCA components. The anti-inflammatory, insulin secretagogue, oxidative-stress reducing, and protective effects against NO-induced neuronal-toxicity might be amongst the possible mechanisms of tested compounds to alleviate NP. Conclusion: Here, we report the isolation and structure elucidation of a novel quinic-acid derivative, KRA. A. syriacus, FKCA, and KRA might be used as a novel complementary approach to ameliorate a variety of painful-syndromes.

Keywords:

Novel quinic acid derivative, Acanthus syriacus, Anti-inflammatory, antinociceptive effects, Kromeic acid

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COI code: JR_AJP-9-3_004

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Raafat, Karim; Mohammad Mehdi Heidari; Mehri Khatami & Vahideh Ghorani, 2019, Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus, Avicenna Journal of Phytomedicine 9 (3), https://www.civilica.com/Paper-JR_AJP-JR_AJP-9-3_004.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Raafat, Karim; Mohammad Mehdi Heidari; Mehri Khatami & Vahideh Ghorani, 2019)
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