Published in: 13th annual international addiction science congress
COI code: KAMED13_335
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors REVIEW ON EFFECT OF BUPROPION ON ATTENUATES METHAMPHETAMINE SELF-ADMINISTRATION IN ADULT MALE RATFatemeh Hajipour - Pharmacognosy research center, School of Pharmacy ,Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Fatemeh Hajipour - Department of Pharmacology ,School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:Background and Aim : Methamphetamine is a highly potent, addictive drug that is widely abused in many countries around the world. methamphetamine produces a general state of well-being along with increased wakefulness, talkativeness, and physical activity and decreased appetite. Behavioral treatment programs have had some success in the treatment of methamphetamine addiction, yet many patients continue to relapse after repeatedly seeking treatment. Thus, pharmacotherapies treatments for methamphetamine addiction are being evaluated. Bupropion is an atypical antidepressant with stimulant properties. This drug has been used off-label to treat methamphetamine addicts, thus prompting the need for systematic investigations of its efficacy. Methods : male wister rats weighing 300-250 g in 5 groups were habituated and conditioned with metamphetamin (1 mg/kg, S.C., for 5 days). After that, primary forced swimming and conditioned place preference (CPP) were tested. They were followed by bupropion (2.5 mg/kg/day, Sc., for 5 days) administration. Finally same tests were performed.Results : Administration of bupropion resulted in a decrement in final preference scores associated with a prime metamphetamine injection (PMI) compared to the primary scores . In a swimming test, bupropion increased the amount of final floating and decreased final activity scores compared with the primary scores.Conclusion : Several questions remain about bupropion’s impact during withdrawal, abstinence, and relapse in a preclinical setting. Research investigating these aspects of addiction will help provide a clearer picture on the effects of bupropion on methamphetamine self-administration in laboratory animals and methamphetamine abuse in humans.
Keywords:methamphetamine; bupropion; cpp; subject-rated drug effects; physiological drug effects
COI code: KAMED13_335
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Hajipour, Fatemeh & Fatemeh Hajipour, 2019, REVIEW ON EFFECT OF BUPROPION ON ATTENUATES METHAMPHETAMINE SELF-ADMINISTRATION IN ADULT MALE RAT, 13th annual international addiction science congress, تهران, مركز تحقيقات سلولي و مولكولي دانشگاه علوم پزشكي ايران, https://www.civilica.com/Paper-KAMED13-KAMED13_335.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Hajipour, Fatemeh & Fatemeh Hajipour, 2019)
Second and more: (Hajipour & Hajipour, 2019)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: Medical University
Paper No.: 2442
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.