Applications of skin tissue engineering in severe burns: a review

Background and Aim : Engineering of biologic skin substitutes has progressed over time from exclusive applications of skin cells, to combinations of cells and scaffolds for treatment and closure of burns. a class of products that is still laden with constraint for clinical utilization. Although the potency to grow autologous keratinocytes helped to reduce the problem of insufficient donor site for mighty burn still have to grapple with insufficient skin allografts which are used as medium wound coating after burns. Alternatives offered by tissue-engineered skin dermal substitiotion have been used fairly successfully. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic origins. Combined use of acellular dermal substitutes with constant skin substitutes containing autologous cells has been shown to provide wound closure in burns. Contray to the access of commercial products, patients suffer from the same problems of high cost, sub-normal skin microstructure and inappropraie engraftment. integration of developmental biology into future models of biologic skin substitutes promises to restitute complete physiology and anatomy, and reduce morbidity from burns. This review focuses on the beginnings of skin tissue engineering, the utilization of some of the key products developed for the treatment of severe burns and the hope of curbing stem cells to improve on current practice

Keywords:

Burns , Skin tissue engineering , Stem cells , Cultured epithelial cells , Dermal substitutes , Regenerative medicine