Effect of 1 adrenoceptors and AT1 receptors on water intakein adult male rats

Publish Year: 1386
نوع سند: مقاله کنفرانسی
زبان: English
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NCSCIE06_195

تاریخ نمایه سازی: 11 شهریور 1391

Abstract:

The present study investigated the effects of 1-adrenoceptors and angiotensinergicsystem on water intake in adalt male rats. Intracerebroventricular ( i.c.v.) injections werecarried out in all experiments after 24-h. deprivation of water. After deprivation, the volum ofconsumed water was measured for 1 h. Administration of losartan, the angiotensin II (ANGII) antagonist (45 g/rat), phenylephrine, 1-adrenergic agonist ( 0.5 g/rat) decreased waterintake, while prazosin, 1-adrenergic antagonist ( 0.25, 0.5 g/rat), increased water intake inisolated rats. Exitatory of water intake by prazosine and attenuate the inhibitory effect oflosartane. on the other hand the addittion of phenylephrine and decreased the inhibitoryresponse of losartan.It is concluded that angiotensinergic and 1-adrenergic system have a close interaction inwater intake mechanisms.

Authors

Majid Navaian

Dept. of Boilogy, Science Faculity,Islamic azad university-shahre rey branch, Tehran Iran

Shahrbanoo Oryan

bDept of biology, Science faculty, Teacher Training University, Dr. Mofatteh

Bahareh Pakpour

Dept. of Boilogy, Science Faculity,Islamic azad university-tehran center branch, Tehran Iran

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