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Title

Evaluation of radiolabeled streptokinase for thrombosis imaging

Year: 1387
COI: JR_IRJNM-16-2_006
Language: EnglishView: 132
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Authors

Amir Reza Jalilian - Agricultural, Medical and Industrial Research School, NSTRI, Karaj, Iran
Fatemeh Mirazizi - Biochemistry Department, Payam-e-Noor University, District ۱۰, Tehran, Iran
Habibolah Nazem - Biochemistry Department, Payam-e-Noor University, District ۱۰, Tehran, Iran
Kammaledin Shafaii - Agricultural, Medical and Industrial Research School, NSTRI, Karaj, Iran

Abstract:

  Introduction: Cardiovascular disease is the major cause of morbidity and mortality in developing and developed countries. Rapid diagnosis of the thrombosis can be an essential step in management of the stroke. Methods: In this work a recently developed radiolabeled streptokinase (STP) tracer was evaluated in an animal thrombotic model using SPECT imaging and biodistribution studies. Locally labeled [67Ga]-Streptokinase was checked by ITLC, HPLC and SDS-PAGE experiments to check the tracer integrity and purity. The biodistribution studies were performed in thrombotic femoral vein of rats using tissue counting and preliminary SPECT studies, respectively (up to 2 h). Results: [67Ga]-Streptokinase prepared with suitable radiochemical purity (HPLC > 95%, ITLC > 99%) was administered to FeCl3 induced thrombotic rats and the percentage of injected dose per gram of tissue (ID/g%) as well as the SPECT images demonstrated the good specific binding of the tracer in thrombotic clots located in heart and aorta 2 hours post injection. Conclusion: [67Ga]-DTPA-STP can be a suitable probe for imaging of thrombosis in cardiovascular diseases. Ga-68 labeled STP has the potential to be an alternative superior labeled compound due to positron emission properties for PET studies as well as appropriate physical half life.

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This Paper COI Code is JR_IRJNM-16-2_006. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1008381/

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Jalilian, Amir Reza and Mirazizi, Fatemeh and Nazem, Habibolah and Shafaii, Kammaledin,1387,Evaluation of radiolabeled streptokinase for thrombosis imaging,https://civilica.com/doc/1008381

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