The Effects of ICD-۸۵ in vivo and in vitro in Treatment of Cancer

Background: Breast cancer is now the most important type of cancer in women around the globe and accounts for ۲۵% of all types of cancer. Prevention and treatment of cancer are essential. Method: The main methods for treating cancer include chemotherapy, surgery, radiotherapy, gene therapy, and hormone therapy. Chemopreventive test programmes began in ۱۹۸۷, when over ۱,۰۰۰ agents and agent combinations were selected and evaluated in preclinical studies of chemopreventive activity against various types of cancers. Results: An important feature of anticancer drugs is a cytotoxic effect on cancer cells; these drugs have some cytotoxic agents found in animal venom. The ICD-۸۵ is a combination of three peptides, ranging from ۱۰,۰۰۰ to ۳۰,۰۰۰ Da, and derived from the venom of the Iranian brown snake (Gloydius halys) and the yellow scorpion (Hemiscorpius lepturus). Conclusion: ICD-۸۵ has an anti-proliferative effect and anti-angiogenesis activity on cancer cells. The side effects of chemotherapy are multiple drug resistance and effects on natural tissues, among others. Therefore, cytotoxic anticancer drugs are useful in treating cancer. The present work investigates the effects of ICD-۸۵ on in vivo and in vitro studies.

Keywords:

Breast Cancer , Gloydius Halys , Hemiscorpius lepturus , ICD-۸۵