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Title

Isolation and characterization of p-Coumaric acid from Diospyros melanoxylon medicinal plant endemic to Western Ghats, India

مجله پیشرفت در تحقیقات بهداشت محیط، دوره: 7، شماره: 4
Year: 1398
COI: JR_JAEHR-7-4_008
Language: EnglishView: 163
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Authors

Anil Kumar K M - Department of Water and Health, JSS Academy of Higher Education and Research, Mysore, India-۵۷۰۰۱۵|Center for Water, Food and Energy, GREENS trust, Harikaranahalli, Dombaranahalli Post, Turuvekere Taluka, Tumkur District, Karnataka, India-۵۷۲۲۱۵
Pallavi S - Department of Water and Health, JSS Academy of Higher Education and Research, Mysore, India-۵۷۰۰۱۵|Center for Water, Food and Energy, GREENS trust, Harikaranahalli, Dombaranahalli Post, Turuvekere Taluka, Tumkur District, Karnataka, India-۵۷۲۲۱۵
H.P. Shivaraju - Department of Water and Health, JSS Academy of Higher Education and Research, Mysore, India-۵۷۰۰۱۵

Abstract:

Diospyros melanoxylon has been traditionally for the treatment of fistula, relieving arthritis, and skin care. The bark extracts of the plant have been investigated in terms of phytochemical and pharmacological potential, while the leaf extract has been untapped. The present study aimed to evaluate the methanol extract of D. melanoxylon (DMM) in terms of the antibacterial (P<0.05), antioxidant (1.2-1.6-fold) and anti-inflammatory potential (IC50: 80 µg/ml). DMM exhibited effective antibacterial, antioxidant, and anti-inflammatory activities at significantly higher levels than the standards. In addition, the HR-LCMS analysis of MBI revealed the presence of a few active compounds, which belonged to the class of phenolic acids and flavonoids at greater concentrations than other phytochemicals (n> 20). The activity-guided repeated fractionation of the methanol extract using silica gel column chromatography yielded a single compound, which exhibited remarkable antioxidant activity. The physicochemical and spectroscopic analyses (UV, IR, 1 H NMR, 13 C NMR, and MS) indicated that the bioactive isolated compound was p-coumaric acid, the effect of which was on par with the standard antioxidant, antibacterial, and anti-inflammatory drugs. Conversely, the effects of the extract on these pharmacological attributes enhanced, confirming that the better activity observed in the study was mainly due to the synergistic effects exerted by various compounds in the extract. In-silico studies have also confirmed the potential of the compound in these effective antibacterial properties. Therefore, the D. melanoxylon extract is a strong therapeutic agent with pharmacological potential.

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This Paper COI Code is JR_JAEHR-7-4_008. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1030071/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
K M, Anil Kumar and S, Pallavi and Shivaraju, H.P.,1398,Isolation and characterization of p-Coumaric acid from Diospyros melanoxylon medicinal plant endemic to Western Ghats, India,https://civilica.com/doc/1030071

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  • Roxburgh W. Flora Indica (Eds Carey W and WallichN). Serampore. ...
  • Wallinofer B. The biology and systematics of Ebenaceae: A review. ...
  • Rathore JS. Diospyros melanoxylon, a bread-winner tree of India. Econ ...
  • Palaparthi S. Pharmacological Profile of Diospyros melanoxylon Methanolic Extract. J ...
  • RathS K, Mohapatra N, Dubey D, PandaS K, Thatoi HN, ...
  • El-Seedi HR, El-Said AM, Khalifa SA, Göransson U, Bohlin L, ...
  • Pragasam SJ, Venkatesan V, Rasool M. Immunomodulatory and anti-inflammatory effect ...
  • Torres y Torres J L, P.N Rosazza J. Microbial transformations ...
  • Lou Z, Wang H, Rao S, Sun J, Ma C, ...
  • Harborne A J. Phytochemical methods: A guide to modern techniques ...
  • Kujala TS, Loponen JM, Klika KD, Pihlaja K. Phenolic andbetacyanins ...
  • Ordonez AAL, Gomez JD, Vattuone MA&amp;Isla MI. Antioxidantactivities of Sechiumedule ...
  • Sun BS, Ricardo-da-Silva JM, Spranger I. Quantification of catechins and ...
  • Nurhanani R, Rasyidah R, Sarni MJ, Azlina AA. Radical scavenging ...
  • Ramith Ramu, Prithvi S Shirahatti, Farhan Zameer, Dhananjaya B Lakkapa, ...
  • Mizushima Y, Kobayashi M. Interaction of anti-inflammatory drugs withserumpreoteins, especially ...
  • Rabia Naz, Hafsa Ayub, Sajid Nawaz, Zia Ul Islam, Tayyaba ...
  • Oyedepo OO, Femurewa AJ. Anti-protease and membrane stabilizingactivities of extracts ...
  • Katsuko Inamatsu. Isolation of P-coumaric acid and sterols from rice ...
  • Elgizawy H, Hussein M A. Isolation, Structure Elucidation of Ferulic ...
  • Feng Guo, Shuoyang Zhang, Xiuying Yan, Yuhan Dan, Jian Wang, ...
  • Zhao Y, Chen MS, Zhao ZG, Yu SJ. The antibiotic ...
  • Pereira JA, Oliveira I, Sousa A, Valentao P, Andrade PB, ...
  • Madikizela B, Aderogba MA, Finnie JF, Van Staden J. Isolation ...
  • Tawata S, Taira S, Kobamoto N, Zhu J, Ishihara M, ...
  • Rice Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships ...
  • PuF, Ren XL, Zhang XP. Phenolic compounds and antioxidant activity ...
  • Casselst BK, Asencio M, Conget P, Speisky H, Videla LA, ...
  • Yin WQ, Duan SQ, Zhang Y, Zeng L, Song XM. ...
  • Al Rashid MH, P.v.p DB, Majumder S, Mandal V, Pal ...
  • Hmar BZ, Mishra S, Pradhan RC. Physico-Chemical, mechanical and antioxidant ...
  • Bhuvana P, Anuradha V, Syed Ali M, Suganya V, Sangeetha ...
  • Bigoniya P, Rana AC. Protective Effect of Wrightiatinctoria Bark Triterpenoid ...

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