The Effects of Vitamin K Supplementation in Vascular Calcification: A Systematic Review

Background: Vascular calcification is a predictor of cardiovascular morbidity and mortality, which can be evaluated by pulse wave velocity (PWV) and Coronary Artery Calcification score (CAC. s). Vitamin K-dependent matrix Gla protein (MGP) is an important inhibitor of calcification. The aim of this systematic review was to assess the effect of high-dose vitamin k supplementation on vascular calcification.  Methods: In this systematic review, a literature search in PubMed was undertaken with using the keywords vitamin k1 supplementation OR phylomenadion supplementation OR vitamin k2 supplementation OR menaquinone supplementation OR vitamin k3 supplementation OR menadion supplementation and calcification , and then qualified articles were used. Results: Vitamin K1 supplement was not associated with  dephosphorylated-uncarboxylated MGP (dp-uc MGP) level and PWV level. However, it was associated with less CAC progression. Vitim K2 supplement was correlated inversely with dp-uc MGP level and decrease in PWV but no difference CAC progression.  Conclusion: Based on results that was obtained from this systematic review, we expressed conclusively that taking vitamin K supplements especially vitamin K2 can decrease inactive MGP levels and slow the progression of CAC in healthy older adults with pre-existing CAC and improve arterial stiffness.

Keywords:

Vitamin K , Matrix Gla Protein (MGP) , Coronary Artery Calcification (CAC) , Pulse Wave Velocity (PWV)