Calcium Fructoborate Nanoparticles: Plant-Based Carrier Boron as Potential Medicine for Neutron Cancer Therapy

Boron neutron capture therapy (BNCT) is efficient therapeutic methods in cancer treatment based on nuclear capture and fission reactions. In this method, use of the best boron-containing agents for boron therapy and boron delivery agent for delivery of them to the infectious site are key points in therapy efficiency. Resaults indicated that calcium fructoborate was the best compound as a boron-containing agent for boron therapy. Furthermore, liposomes can effectively and selectively deliver large quantities of boron to tumors and that the compounds delivered by liposomes have longer tumor retention time. Indeed, liposomal encapsulation of calcium fructoborate has been extensively evaluated as nanovehicles for the delivery of boron compounds for BNCT.In this paper, we deeply investigate molecular composition of the calcium fructoborate used as a carrier supplement for cancer therapy, by using FT-IR, XRD, TG, DSC and Raman spectroscopic analysis. The experimental measurements agree very well with the molecular formula Ca[(C6H10O6)2B]24H2O.

Keywords:

Boron neutron capture therapy , calcium fructoborate , liposome encapsulation