Postoperative Extra-Cranial Metastasis of Glioblastoma: A Case Report
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 16، Issue: 1
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-16-1_013
تاریخ نمایه سازی: 26 آذر 1399
Abstract:
Glioblastoma (WHO grade IV) is the most common malignant tumor of neural tissues in adults as a primary tumor. Because of blood brain barrier and short median survival of patients with glioblastoma, metastasis of this tumor is very rare. A 46-year-old man was admitted to Sina hospital with chief complaint of headache and visual impairment. After neuro-radiologic evaluation the patient underwent surgery. Pathologic examination of the tumor confirmed the diagnosis of glioblastoma multiforme. Cytogenetic study of the tumor cells confirmed GBM IDH1 wild type with TERT mutation and EGFR amplification. Two months after surgical resection, the tumor recurred with involvement of the dura matter. After the second operation, metastasis to the pelvic cavity and cervical lymph node was found. Almost all cases of glioblastoma metastasis had undergone surgery or any manipulation; this fact suggests that iatrogenic intra-vascular seeding of tumor cells at the time of resection and disruption of blood brain barrier could cause extra-neural metastasis.
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Authors
atieh zandnejadi
Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Arezoo Eftekhar-Javadi
Department of Pathology, Sina hospital, Tehran University of Medical Sciences, Tehran, Iran
HEDIEH MORADI TABRIZ
Tehran University of Medical Sciences
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