Stimulation of dendritic cell functional maturation by capsid protein from chikungunya virus

Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-23-10_004

تاریخ نمایه سازی: 19 دی 1399

Abstract:

Objective(s): Chikungunya virus (ChikV) infection is characterized by persistent infection in joints and lymphoid organs. The ChikV Capsid protein plays an important role in regulating virus replication. In this study, we hypothesized that capsid protein may stimulate dendritic cell (DC) activation and maturation and trigger an inflammatory response in mice. Materials and Methods: Mice were intraperitoneally injected with capsid protein and examined for changes in immunophenotype in lymph nodes (LNs). Next, DCs were treated with capsid protein or LPS and then expression of maturation markers, cytokine production, and ability to stimulate CD4+ T cells in allo-MLR were analyzed.Results: Injection of mice with capsid protein led to recruitment of myeloid cells and increased activation of T lymphocytes in LNs. Importantly, treatment of DCs with capsid protein prolonged the activation of IKB-α and up-regulated the number of CD11c+CD86+DCs and release of TNF-α and IL-12p70 as well as reducing DC apoptosis, all effects were abolished in the presence of Bay 11-7082. In addition, IL-2 production was higher by CD4+ T cells stimulated with capsid-treated as compared with LPS-induced DCs. Conclusion: The observations revealed that capsid protein participates in the regulation of NF-κB signaling and maturation of DCs.

Keywords:

Chikungunya virus Cytokine Dendritic cell MAPK NF , κB

Authors

Vu Nghia

Department of Pathophysiology, Vietnam Military Medical University, Ha Dong, Hanoi, Vietnam

Nguyen Giang

Faculty of Biotechnology, Vietnam National University of Agriculture, Gia Lam, Hanoi, Vietnam

Nguyen Canh

Graduate University of Science and Technology, Vietnam Academy of Science and Technology, ۱۸ Hoang Quoc Viet, Cau Giay, Ha Noi, Vietnam

Nguyen Ha

Institute of Genome Research, Vietnam Academy of Science and Technology, ۱۸ Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Nguyen Duong

Institute of Genome Research, Vietnam Academy of Science and Technology, ۱۸ Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Nguyen Huy Hoang

Institute of Genome Research, Vietnam Academy of Science and Technology, ۱۸ Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Nguyen Xuan

Institute of Genome Research, Vietnam Academy of Science and Technology, ۱۸ Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

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