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Antibacterial Activity of Bis(Indolyl) Methane Derivatives against Staphylococcus Aureus

Publish place: Advanced Journal of Chemistry-Section A، Vol: 3، Issue: 6
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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لینک ثابت به این Paper:
https://civilica.com/doc/1141840

شناسه ملی سند علمی:

JR_AJCS-3-6_002

تاریخ نمایه سازی: 22 دی 1399

Abstract:

In the present study, we successfully synthesized a series of indoles with a variety of aromatic aldehydes via one-pot route. The excellent results of the bis(indoly) methane (BIM) derivatives was obtained at the presence of 5.0 mol% p -toluene sulfonic acid in acetonitrile at room temperature using conventional process. All the as-synthesized compounds were bioactive. The synthesized BIM derivatives were evaluated for the antibacterial activity (in vitro) against the Staphylococcus aureus, and the results were compared with the standard Kanamycin. The results confirmed that, majority of the as-synthesized compounds revealed splendid antibacterial activity.

Keywords:

Antibacterial Activity , Bis(indolyl) methane derivatives , Catalyst , Kanamycin , Staphylococcus aureus (MTCC1144)

Authors

Anil Kumar Bahe

Heterocyclic Synthesis and Electro Analytical Laboratory, Department of Chemistry, Dr. Harisingh Gour Central University, Sagar, India

Ratnesh Das

Heterocyclic Synthesis and Electro Analytical Laboratory, Department of Chemistry, Dr. Harisingh Gour Central University, Sagar, India

Gowhar Ahmad Naikoo

Department of Mathematics and Sciences, College of Arts and Applied Sciences, Dhofar University, Salalah ۲۱۱, Sultanate of Oman

Pankaj Kosti

Heterocyclic Synthesis and Electro Analytical Laboratory, Department of Chemistry, Dr. Harisingh Gour Central University, Sagar, India

Sushil Kashaw

Department of Pharmaceutical Science, Dr. Hari Singh Gour University, Sagar (M.P.), India

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