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Title

SIRT1 Gene Polymorphisms Are Associated with Urinary Bladder Cancer in an Iranian Population

Year: 1398
COI: JR_RBMB-8-2_014
Language: EnglishView: 45
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Authors

Zahra Shafieian - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Gholamreza Bahari - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Mohammad Hashemi - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. & Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Alireza Nakhaee - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. & Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Abstract:

Background: The present study was undertaken to evaluate the possible association between silent information regulator of transcription 1 gene (SIRT 1) polymorphisms and risk of urinary bladder cancer (UBC) in an Iranian population. Methods: The SIRT1 polymorphisms rs3758391 T/C and rs369274325 G/A were evaluated in 120 Iranian bladder cancer patients and 118 healthy individuals as the control group. The SIRT1 rs369274325 G/A and rs3758391 T/C polymorphisms were genotyped using tetra-primer ARMS PCR and PCR-RFLP methods, respectively. Results: The SIRT1 rs3758391 TT genotype occurred significantly more frequently in the UBC patients than in the controls (13.3 vs. 1.7%) in both the additive and recessive models due to a significant difference in either of additive (TT vs. CC; OR= 9.529, P = 0.003) or recessive models (TT vs. CC + CT genotype; OR= 8.923, P = 0.002). Also, for rs369274325, the AG genotype was found in a significantly greater percentage of UBC patients than in controls (75.8 vs. 43.2%, respectively, P < 0.0001. Conclusions: Our preliminary study suggests that SIRT1 rs3758391 T/C and rs369274325 G/A polymorphisms may confer an increased risk of bladder cancer in our patients.

Keywords:

Gene polymorphism, Urinary Bladder Neoplasms.

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This Paper COI Code is JR_RBMB-8-2_014. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1141936/

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Shafieian, Zahra and Bahari, Gholamreza and Hashemi, Mohammad and Nakhaee, Alireza,1398,SIRT1 Gene Polymorphisms Are Associated with Urinary Bladder Cancer in an Iranian Population,https://civilica.com/doc/1141936

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Type of center: علوم پزشکی
Paper count: 1,263
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