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Title

Association of Vitamin D Status with the Severity and Mortality of Community-Acquired Pneumonia in Iran during 2016-2017:A Prospective Cohort Study

مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 8، شماره: 1
Year: 1398
COI: JR_RBMB-8-1_014
Language: EnglishView: 71
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Authors

Fatemeh Talebi - Department of Infectious Disease and Tropical Diseases, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mehrnaz Rasooli nejad - Professor of Infectious Diseases, Iranian Research Center for HIV/AIDS, Department of Infectious Diseases, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi Yaseri - Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Azar Hadadi - Professor of Infectious Diseases, Research Development Center, Sina hospital, Tehran University of Medical Sciences, Tehran, Iran.

Abstract:

Background: Community-acquired pneumonia (CAP) is a common disease considered as a major public health problem. It causes considerable morbidity and mortality despite antibiotic treatments. Hospital admission of CAP patients is a significant financial burden and many efforts are ongoing to decrease hospital stay durations. Vitamin D deficiency is associated with increased risk of respiratory infections. This study was designed to determine the association of vitamin D status with hospitalized CAP patient mortality and disease severity. Methods: This prospective cohort study examined 180 CAP patients admitted to a teaching Hospital in Tehran, Iran during 2016-2017. Their demographic and anthropometric characteristics were recorded. The disease severity was evaluated based on CURB-65. Vitamin D status was determined by measuring by serum 25-hydroxylated vitamin D (25(OH)D) with ELISA. The patients were followed for 30 days to evaluate their vitality. Results: One hundred and eighty pneumonia patients, including 104 males and 84 females, were recruited from respiratory disease, infectious disease, emergency, and ICU wards. Nearly 18% of the patients were current smokers. The CAP severity, evaluated by CURB-65, was determined to be non-severe in 74.4% of the patients. Patients were classified as vitamin D sufficient, insufficient, or deficient. Thirty percent of the patients were vitamin D sufficient, 18% were insufficient, and 52% were deficient. Thirty-day mortality was 40% (72 cases). Mortality was greater in males than in females (47.1% vs. 30.3%, p=0.03). The disease was significantly less severe in the patients who survived than in those who did not. The vitamin D status differed between males and females (p=0.027). The vitamin D status was lower in the more severe cases than in the less (p=0.036), and vitamin D deficiency was more prevalent in patients who died than in those who lived. Vitamin D concentration was negatively correlated with hospital stay duration. The 25(OH)D concentration was significantly greater in patients who survived than in those who did not (p<0.001). Conclusions: Pneumonia severity and mortality risk were greater and hospital stays longer in vitamin D-deficient patients than in those with higher vitamin D status.

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This Paper COI Code is JR_RBMB-8-1_014. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1141951/

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Talebi, Fatemeh and Rasooli nejad, Mehrnaz and Yaseri, Mehdi and Hadadi, Azar,1398,Association of Vitamin D Status with the Severity and Mortality of Community-Acquired Pneumonia in Iran during 2016-2017:A Prospective Cohort Study,https://civilica.com/doc/1141951

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Type of center: علوم پزشکی
Paper count: 9,384
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