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Title

The Association Between the Transforming Growth Factor Beta-1 -509C>T Gene Polymorphism and Primary Open Angle Glaucoma in North Eastern Iran

مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 7، شماره: 2
Year: 1397
COI: JR_RBMB-7-2_007
Language: EnglishView: 119
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Authors

Akbar Derakhshan - Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Jalil Tavakkol Afshari - Immunogenetic and cell culture department, immunology research center, school of medicine, Mashhad University of Medical Sciences, Mashhad, Iran. & Department of allergy and immunology, school of medicine, Mashhad University of Medical Sciences, Mashhad,
Javad Sadeghi Allah Abadi - Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Amin Reza Nikpoor - Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. & Immunogenetic and cell culture department, immunology research center, school of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ramin Daneshvar - Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Saeed Shokoohi Rad - Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad-Reza Ansari-Astaneh - Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract:

Background: Glaucoma is a common cause of irreversible blindness. Transforming growth factor beta-1(TGF-β1) is the main isoform of TGF-β superfamily in the eye. Overexpression of TGF-β1 is shown to be related with the glaucoma. Studies have shown that the presence of mutant T allele of TGF-β1 -509C>T polymorphism (rs1800469) is associated with increased gene expression. So, in present study, association of the TGF-β1-509C>T gene polymorphism and primary open angle glaucoma (POAG) in patients from north east of Iran was investigated. Methods: A case-control study was conducted on 112 POAG patients and 112 control participants. TGF-β1-509C>T genotyping was done by PCR-restriction fragment length polymorphism (PCR-RFLP) method using Bsu36I restriction enzyme. Moreover, cup to disk ratio(CDR), intraocular pressure (IOP) and visual acuity (VA) were measured. The obtained results were statistically analyzed. Results: The highest frequency of genotype in the control group was related to CC genotype (44.6%), but the heterozygous CT genotype (45.6%) was observed as the highest frequency of genotypes in patient group (P value: 0.022, OR for TT genotype: 2.54 CI95% for OR: 1.22, 5.27). Also, the frequency of the T mutant allele showed a significant difference between case and control groups (P value: 0.005, OR: 1.73 CI95% for OR: 1.18, 2.53).   Conclusions: In conclusion, a significant association was seen between TGF-β1 -509C>T gene polymorphism and POAG disease and inheritance of mutant T allele is considered to be a risk factor for glaucoma in patients living in North Eastern part of Iran.  

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This Paper COI Code is JR_RBMB-7-2_007. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Derakhshan, Akbar and Tavakkol Afshari, Jalil and Sadeghi Allah Abadi, Javad and Nikpoor, Amin Reza and Daneshvar, Ramin and Shokoohi Rad, Saeed and Ansari-Astaneh, Mohammad-Reza,1397,The Association Between the Transforming Growth Factor Beta-1 -509C>T Gene Polymorphism and Primary Open Angle Glaucoma in North Eastern Iran,https://civilica.com/doc/1141959

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Type of center: علوم پزشکی
Paper count: 8,070
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