Fabrication of Erythromycin loaded Poly vinyl alcohol and Ethyl cellulose polymeric films for wound healing drug delivery
Publish place: 7th National Congress in Chemistry and Chemical Engineering with emphasis on Iranian indigenous technologies
Publish Year: 1399
Type: Conference paper
Language: English
View: 343
This Paper With 5 Page And PDF Format Ready To Download
- Certificate
- I'm the author of the paper
Export:
Document National Code:
CBGCONF07_154
Index date: 30 January 2021
Fabrication of Erythromycin loaded Poly vinyl alcohol and Ethyl cellulose polymeric films for wound healing drug delivery abstract
In this study, we aimed to investigate the efficacy of Polyvinyl alcohol (PVA) and Ethylcellulose (EC) films as topical wound dressing systems for the sustained release of Erythromycin (EM). The drug loaded PVA and EC films were characterized by FTIR, and the obtained spectra showed a good dispersion of drug in the polymers without any chemical reaction. Additionally, mechanical specifications of the prepared formulations were investigated. It was shown that EC has better swelling behavior in comparison with PVA. The invitro release profiles of EM was recorded at 25˚C. EM has shown initial burst release from both formulations, lasting 22 and 48 hours for PVA and EC based formulations, respectively. The results showed that EC has more extended drug release path, and proves to be an efficient drug carrier for EM.
Fabrication of Erythromycin loaded Poly vinyl alcohol and Ethyl cellulose polymeric films for wound healing drug delivery Keywords:
Fabrication of Erythromycin loaded Poly vinyl alcohol and Ethyl cellulose polymeric films for wound healing drug delivery authors
Nasrin Aliasgharlou
Department of Science, University of Urmia, Urmia, Iran
Farzin Asghari Sana
Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia ،Iran
Pezhman Zolfaghari
Department of Chemical Engineering, Faculty of Chemical and Petroleum Engineering,University of Tabriz,, Iran.