Evaluation of the Expression of NLRP1 Inflammasome in Patients with Bacterial Septicemia
Publish place: Iranian Journal of Medical Microbiology، Vol: 14، Issue: 3
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
View: 248
This Paper With 12 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJMM-14-3_002
تاریخ نمایه سازی: 10 اسفند 1399
Abstract:
Background: Septicemia is the most important cause of mortality, especially in hospitalized patients, due to the influence of the immune response by infection. NLRP1 (Nod-like receptor P1) is an intracellular receptor that recognizes microbial-dependent molecular patterns. The main intracellular mechanism of anti-septicemia is still being investigated. The purpose of this study was to evaluate the expression of NLRP1 genes in patients with septicemia compared to healthy controls.
Materials & Methods: This cross sectional study was done on 40 blood samples in patient with septicemia and 40 healthy controls using quota sampling. Bacterial species were identified by microbial culture. NLRP1 gene expression was evaluated using Real Time PCR technique.
Results: Four bacteria such as Escherichia coli, Staphylococcus aureus, Acinetobacter baumannii and Pseudomonas aeruginosa reported for causes of septicemia. The results also showed that the expression of NLRP1 inflammasome at mRNA level was significantly increased in patients with septicemia compared to healthy controls. NLRP1 gene expression was not different among patients with different bacterial infections.
Conclusion: NLRP1 appears to be an important receptor against bacteria during bacterial bloodstream infection, and further research, particularly in reducing the expression level of NLRP1 molecules, may play a key role in blood decontamination.
Keywords:
Septicemia , NLRP1 (Nod-like receptor P1) , gene expression , سپتیسمی , (NLRP1) Nod-like receptor P1 , بیان ژن
Authors
Hamid Mousahasankhani
Department of Microbiology, Faculty of Science, Kerman Branch, Islamic Azad University, Kerman, Iran
Ashraf Kariminik
Department of Microbiology, Faculty of Science, Kerman Branch, Islamic Azad University, Kerman, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :