Sulforaphane response on aluminum- induced oxidative stress, alterations in sperm characterization and testicular histomorphometry in Wistar rats

Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
View: 179

This Paper With 14 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

این Paper در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJRM-18-8_006

تاریخ نمایه سازی: 17 فروردین 1400

Abstract:

Background: The exposure of male individual to environmental toxicant is regarded as a channel that results in reduced sperm counts and infertility. Objective: This study investigated the ameliorative response of Sulforaphane (SFN) on Aluminum trichloride (AlCl3) induced testicular toxicity in adult male Wistar rats. Materials and Methods: A total of 32 adult male Wistar rats (180-200 gm between 8-10 wk) were divided into four groups (n = 8/each). Group A) received distilled water orally as placebo; Group B) received 100 mg/kgbw AlCl3 only orally; Group C) received 100 mg/kgbw AlCl3 and 100 mg/kgbw SFN orally; and Group D) received 100 mg/kgbw SFN only orally. After 28 days of experiment, animals underwent cervical dislocation, blood serum was obtained for analysis, and testes were harvested for biochemical assays, histology, hormonal profile, and sperm characterization. Results: The sperm parameters showed a significant difference within the AlCl3 only group compared with the control and SFN only groups (p = 0.02). However, AlCl3 and SFN co-treatment showed improvement in the motility, viability, and sperm count compared with the AlCl3 only group (p = 0.02). Furthermore, there was a significant decline in the levels of hormones profile and antioxidant status in AlCl3 only group compared to the control and SFN only (p = 0.02). The testicular histoarchitecture of the AlCl3 only group showed shrinkage of seminiferous tubules, spermatogenesis disruption, and empty lumen compared to the control and SFN only groups. Conclusion: The present study revealed the ameliorative response of SFN on AlCl3-induced testicular toxicity on serum hormone profiles, antioxidant status, lipid peroxidation, and histomorphometric analysis through oxidative stress.  

Authors

Babatunde Ogunlade

Department of Human Anatomy, Federal University of Technology, Akure, Ondo State, Nigeria.

Sunday Adelakun

Department of Human Anatomy, Federal University of Technology, Akure, Ondo State, Nigeria.

Kingsley Iteire

Department of Human Anatomy, University of Medical Sciences, Ondo city, Ondo State, Nigeria.

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Nordkap L, Joensen UN, Blomberg Jensen M, Jørgensen N. Regional ...
  • Mehrpour O, Karrari P, Zamani N, Tsatsakis AM, Abdollahi M. ...
  • Verstraeten SV, Aimo L, Oteiza PI. Aluminum and lead: Molecular ...
  • Venturini-Soriano M, Berthon G. Aluminum speciation studies in biological fluids. ...
  • Yousef MI, Salama AF. Propolis protection from reproductive toxicity caused ...
  • Choi EJ. Antioxidative effects of hesperetin against 7, 12- dimethylbenz ...
  • Gurjar M, Baronia AK, Azim A, Sharma K. Managing aluminum ...
  • Hirata A, Murakami Y, Shoji M, Kadoma Y, Fujisawa S. ...
  • Anand R, Kumari P, Kaushal A, Bal A, Wani WY, ...
  • Zhao Z, Liao G, Zhao Q, Lv D, Holthfer H, ...
  • Lee JH, Moon MH, Jeong JK, Park YG, Lee YJ, ...
  • Choi KM, Lee YS, Kim W, Kim SJ, Shin KO, ...
  • Bahadoran Z, Tobidi M, Nazeri P, Mehran M, Azizi F, ...
  • De Souza CG, Sattler JA, de Assis AM, Rech A, ...
  • Bai Y, Cui W, Xin Y, Miao X, Barati MT, ...
  • Shan Y, Zhao R, Geng W, Lin N, Wang X, ...
  • Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, ...
  • Ushida Y, Talalay P. Sulforaphane accelerates acetaldehyde metabolism by inducing ...
  • Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, ...
  • Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, ...
  • Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, ...
  • Gaona-Gaona L, Molina-Jijón E, Tapia E, Zazueta C, Hernández-Pando R, ...
  • Talalay P, Fahey JW, Healy ZR, Wehage SL, Benedict AL, ...
  • Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, ...
  • Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, ...
  • Kikuchi M, Ushida Y, Shiozawa H, Umeda R, Tsuruya K, ...
  • Zhang Y, Tang L. Discovery and development of sulforaphane as ...
  • Avwioro OG. Histology and tissue pathology. Principles and techniques. 2nd ...
  • Feng R, He W, Ochi H. A new murine oxidative ...
  • World Health Organization. WHO laboratory manual for the examination of ...
  • Adelakun SA, Ukwenya VO, Ogunlade BS, Aniah JA, Ibiayo AG. ...
  • Akang EN, Oremosu AA, Osinubi AA, Dosumu OO, Kusemiju TO, ...
  • Howard CV, Reed MG. Unbiased stereology: Three-dimensional measurement in microscopy. ...
  • Baines H, Nwagwu MO, Hastie GR, Wiles RA, Mayhew TM, ...
  • Jørgensen N, Vierula M, Jacobsen R, Pukkala E, Perheentupa A, ...
  • Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for ...
  • Geoffroy-Siraudin C, Loundou Ad, Romain F, Achard V, Courbiere B, ...
  • Cheraghi E, Golkar A, Roshanaei K, Alani B. Aluminium-induced oxidative ...
  • Franca LR, Godinho CL. Testis Morphometry, Seminiferous Epithelium Cycle Length, ...
  • Pandey G, Jain GC. Aluminium chloride-induced testicular effects in rats: ...
  • Trif A, Muselin F, Argherie D, Dumitrescu E, Măcinic I. ...
  • Saleh RA, Agarwal A. Oxidative stress and male infertility: from ...
  • Bansal AK, Bilaspuri GS. Impacts of oxidative stress and antioxidants ...
  • Akinloye O, Arowojolu AO, Shittu OB, Anetor JI. Cadmium toxicity: ...
  • Isaac JA, Bolanle AM, Oluyemi A. Modulatory effects of kolaviron ...
  • Al-Attar AM. Antioxidant effect of vitamin E treatment on some ...
  • Guo CH, Lin CY, Yeh MS, Wang Hsu GS. Aluminum-induced ...
  • Yakubu OE, Nwodo OFC, Imo C, Ogwoni HA. Spermatogenic and ...
  • Nuhair RS. Effects of aluminum chloride on some hormones levele ...
  • Dobashi M, Fujisawa M, Yamazaki T, Okuda Y, Kanzaki M, ...
  • Dobashi M, Fujisawa M, Yamazaki T, Okuda Y, Kanzaki M, ...
  • Shahraki MR, Zahedi Asl S, Sarkaki AR. The effect of ...
  • Sikka SC, Rajasekaran M, Hellstorm WJ. Role of oxidative stress ...
  • Rao MV, Gangadharan B. Antioxidative potential of melatonin against mercury ...
  • Anane R, Creppy EE. Lipid peroxidation as pathway of aluminium ...
  • Turner RMO. Pathogenesis, diagnosis, and management of testicular degeneration in ...
  • Khattab FKI. Histological and ultrastructural studies on the testis of ...
  • Kang IS, Kim C. Taurine chloramine administered in vivo increases ...
  • Kim C, Cha YN. Taurine chloramine produced from taurine under ...
  • Kim W, Kim HU, Lee HN, Kim SH, Kim C, ...
  • Ahmed YF, Mahmoud GHMK, Farghaly AA, Abo-Zeid MA, Ismail EM. ...
  • Aruldhas MM, Subramanian S, Sekar P, Vengatesh G, Chandrahasan G, ...
  • Pires VC, Gollucke APB, Ribeiro DA, Lungato L, Almeida VD, ...
  • نمایش کامل مراجع