The Effect of Training at Different Temperatures on The Gene Expression of GLUT4 and Insulin Receptor in the Brown Adipose Tissue of Streptozotocin-Induced Diabetic Rats

Background and Objective: Diabetes is one of the health problems in all societies. The aim of the present study was to investigate the effect of a period of training at different temperatures on the gene expression of GLUT_4 and insulin receptor in the brown adipose tissue of diabetic rats. Material and Methods: In this experimental study, 21 diabetic rats were randomly divided into 3 groups of 7 animals, including: (1) control (C), (2) swimming training at 5° C (S5ºC), and (3) swimming training at 36° C (S36ºC). Water swimming training was performed at 5±2° C and 36±2° C for six weeks, 5 sessions per week and 2-4 minutes per session. Data were analyzed using one-way analysis of variance and Tukey’s post hoc test at the significance level of p≤0.05. Results: The gene expression of GLUT4 and insulin receptor in the S5º C and S36º C groups was significantly (P = 0.0001) higher than the control group. Also, the gene expression of GLUT4 in the S36º C group was higher than the S5º C group (p = 0.001), and the expression of insulin receptor in the S5º C group was significantly (p = 0.001) higher than the S36º C group. Conclusion: Swimming training at 5º C and 36º C significantly increased the gene expression of GLUT4 and insulin receptor in the brown adipose tissue of diabetic rats.

The Effect of Training at Different Temperatures on The Gene Expression of GLUT4 and Insulin Receptor in the Brown Adipose Tissue of Streptozotocin-Induced Diabetic Rats Keywords:

Physical Education and Training , GLUT4 , Insulin Receptor , Diabetes