Novel function of Nanos۲ in expression of innate immunity genes and its probable roles in maintenance of pluripotency state

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-24-4_015

تاریخ نمایه سازی: 6 اردیبهشت 1400

Abstract:

Objective(s): Cell-based therapeutic approaches have witnessed significant developments during the last decade especially after approval of MSCs based treatment of graft versus host disease. Several cell-based approaches have shown immunomodulatory behavior during regeneration following the unknown cascade of events but the exact mechanisms are yet to be defined. Clinical applications of cell-based drugs are hampered all over the world because of incomplete understanding of molecular mechanisms requiring the application of mechanistic approaches to solving the mystery. Current work has given us the idea that Nanos۲ enhances the cellular pluripotency characteristics while down-regulating the innate immunity genes, simultaneously.Materials and Methods: The immunomodulatory behavior of cells was studied against cells carrying the ectopic expression of Nanos۲ in comparison with Stella and Oct۴ individually and simultaneously using SON vector (Stella, Nanos۲ and Oct۴). Results: It was observed that overexpression of Nanos۲ leads to down-regulation of Interferon-Stimulated Genes (ISGs)-mRNAs such as Ifitm۱, lsg۱۵, Oas۲, and Oas۱۲. Nanos۲ overexpressing MEF cells have shown restrictive inflammatory effects when cells were treated with inflammatory stimuli such as LPS and Poly (I:C). Conclusion: From our recent findings in line with many others, it can be concluded that Nanos۲ acts as a coin with two sides, regulating pluripotency and immunity together which enhances resistance against inflammatory stimuli. Nanos۲ could be a potential candidate as a molecular drug for management of inflammation and immunomodulation but it requires a comprehensive comparative expression analysis of innate immunity genes in vitro and in vivo.

Keywords:

Acetylsalicylic acid Anti , oxidants Epididymis Melatonin Sperm Testosterone

Authors

Monireh Bahrami

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Maryam Moghaddam Matin

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Moein Farshchian

Stem Cell and Regenerative Medicine Research Group, Iranian Academic Center for Education, Culture and Research (ACECR) Razavi Khorasan, Mashhad Branch, Iran

Molood Asadi

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Ahmad Reza Bahrami

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

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