The protective effect of Azadirachta indica (neem) against metabolic syndrome: A review
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 24، Issue: 3
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-24-3_003
تاریخ نمایه سازی: 6 اردیبهشت 1400
Abstract:
Metabolic syndrome is a condition associated with obesity, diabetes, dyslipidemia, and high blood pressure. Recently, the use of phytochemicals is suggested in the control and treatment of metabolic syndrome. The Azadirachta indica (neem) is an evergreen tree belonging to the family of Meliaceae. Multiple studies have been confirmed the anti-diabetic and anti-hypertension, anti-hyperlipidemia, and anti-obesity effects of neem. In this review, we reported the protective effects of neem against the complications of metabolic syndrome with a special focus on mechanisms that are involved. It has been shown that neem can control hyperglycemia and hypertension through over-expression of transcription factor nuclear factor erythroid ۲–related factor ۲ (Nrf۲) and anti-oxidant effects. Neem also reduced the glucose uptake through up-regulation of glucose transporter ۴ (GLUT۴) and inhibition of key intestinal enzymes such as glucosidases. Moreover, neem showed anti-hypertensive effects possibility via the block of calcium channels, up-regulation of endothelial nitric oxide synthase (eNOS), and extracellular signal-regulated kinases ۱/۲ (ERK۱/۲) signaling pathway. Anti-oxidant effects play an important role in protective mechanisms of neem against metabolic syndrome and its complications.
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Authors
Fatemeh Yarmohammadi
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
Soghra Mehri
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Nahid Najafi
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
Sanaz Salar amoli
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
Hossein Hosseinzadeh
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
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