Effect of Fluoxetine on Ovarian and Oviduct Tissue in Female Mature Balb/C Mice

Background and Objective: Use of antidepressants such as fluoxetine, which is widely used worldwide and easily accessible to the public, causes complications such as temporary or permanent infertility. The present study was conducted to investigate the effects of fluoxetine on the ovaries and oviducts of mature female Balb/C mice. Materials and Methods: In this study after determining the appropriate dose of fluoxetine, it was injected intraperitoneally (IP) for ۳۰ days into ۷۵ adult Balb/C mice with doses of ۱۵ mg/kg (group ۱), ۲۰ mg /kg (group ۲), ۲۵ mg /kg (group ۳), control group (non-injection) and sham (distilled water injection). ANOVA analysis and Duncan test were used to compare the means with significant levels being considered (P<۰.۰۵) and (P <۰.۰۰۱). Results: During macroscopic examination, significant ovary weight decrease was observed in all three doses (P <۰.۰۰۱) and in microscopic studies, reduction of the small and large diameter, number of graph follicles and corpus luteum were observed (P <۰.۰۵ and P <۰.۰۰۱ respectively). Meanwhile, an increase in the number of degenerative follicles and damaged zona pellucidas was significant (P <۰.۰۰۱ and P <۰.۰۵), and oviduct diameter was significantly higher than the control group (P <۰.۰۵). Conclusion: It can generally be concluded that fluoxetine has a damaging effect on ovarian and oviduct tissue of mice.

Keywords:

Fluoxetine , ovary , oviduct , follicle , mice