Investigating the Effect of Vitamin D Supplementation on Maternal Serum ۲۵(OH)D Levels

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_JMREH-9-2_002

تاریخ نمایه سازی: 11 اردیبهشت 1400

Abstract:

Background & aim: Although evidence confirms the importance of vitamin D supplementation in pregnancy, there is still a debate over the adequate daily doses of vitamin D intake. This study aimed to investigate the effect of ۴۰۰ and ۱,۰۰۰ IU vitamin D/day on maternal serum ۲۵ (OH) D levels. Methods: This quasi-experimental study was carried out on ۷۴ healthy pregnant women between June ۱۲ and September ۲۲, ۲۰۱۹. The intervention group (n=۴۴) received ۱,۰۰۰ IU vitamin D/day from ۸ to ۱۰ weeks of pregnancy for ۱۷ weeks, while the control group (n=۳۹) took multivitamin supplements (۴۰۰ IU vitamin D/day) from ۱۶ weeks of pregnancy for ۱۲ weeks. Maternal serum ۲۵ (OH) D levels were measured at ۲۵-۲۸ weeks of gestation. Data were analyzed in SPSS software (version ۲۱) through the Chi-square, Student’s t-test, Mann-Whitney U, and linear regression tests.  Results: There was no significant difference between the two groups at the beginning of the study in terms of ۲۵ (OH) D concentration (P=۰.۲۳). The intake of ۱,۰۰۰ IU vitamin D/day had a significant (β=۰.۲۸, p <۰.۰۰۱), yet small effect (effect size=۰.۳۰), on increasing serum ۲۵ (OH) D levels after controlling the confounding variables. About half of the females who took ۱,۰۰۰ IU vitamin D/day had a serum ۲۵(OH) D level less than ۳۰ ng/dl at ۲۵-۲۸weeks of pregnancy. Conclusion: Even after receiving ۱,۰۰۰ IU/day Vitamin D, vitamin D insufficiency was still prevalent during the second trimester of pregnancy. It seems that a higher dosage of vitamin D is required for pregnant women. 

Authors

Zahra Moudi

Assistant Professor, Pregnancy Health Research Center, Zahedan University of Medical Sciences Zahedan, Iran

Zahra Ayati

MSc in Midwifery Counselling, Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Hossein Ansari

Assistant Professor, Department of Epidemiology and Biostatistics, Zahedan University of Medical Sciences, Zahedan, Iran

Seyed Mehdi Tabatabaei

Assistant Professor, Pregnancy Health Research Center, Zahedan University of Medical Sciences Zahedan, Iran

Mahdieh Sheikhi

PhD Student in Food and Nutrition Policy, Family Health Office, Zahedan University of Medical Sciences, Zahedan, Iran

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