Investigation of anti-epileptic drugs effects on genes expression changes associated with development of male mice gonads

Background and Aim: Epilepsy is one of the most prevalent neurological disorders that it affects about ۱% of the world Society. In the most times, management of seizures is an obstacle without antiepileptic drugs. Many studies have confirmed unfavorable side effects of these drugs. One of the most important subjects in drug diets is suppressive and toxic effects of drug in sexual gonads biology that may be lead to infertility.Methods: In the present study, by study of information collected from a lot of previous researches, important key genes such as SOX۹, WT۱ and LIF were selected in male gonads development and relevant gene networks was drawn by computational modeling using Cytoscape software and STRING server. In the next step, by investigation the effect of Lamotrigenin and Carbamazepine drugs and possible interactions with effective genes and molecules in the developmental pathway was predicted possible pattern of gene expression pathway and blocking or creating inter-network paths.Results: Our results have shown that the above antiepileptic drugs can disrupt the natural development of male gonads by affecting on the mentioned pathways.Conclusion: These results emphasize the necessary to consider these interferences in design and improvement of drug technology. The laboratory experiments and gene expression analysis is ongoing by our research group.

Keywords:

Anti-epileptic drugs , Gene Network , Male Infertility , Gonad development