Thrombotic proteins and recurrent abortion

Background and Aim: Introduction Infertility due to recurrent abortion is the common clinical problem in fertility clinics. The research for finding etiology of recurrent abortion, is led to highlight the “thrombotic factors” role in this situation. This work showed the relation between these proteins defect in molecular view in women who suffer from recurrent abortion and consequent infertility.Methods: We studied Prothrombin gene G۲۰۲۱۰A mutation, Factor V Leiden, Fibrinogen, MTHFR mutation and PAI۱ in ۴۵ Caucasian infertile women referred to Fertility Center of the private Sarah infertility center and Aryagen private medical genetics laboratory using Rt-PCR, PCR-sequencing methods of whom ۴۰ with unexplained, female infertility, and failed to natural pregnancy.Results: A significant relationship between inherited thrombophilia [OR ۹۵%CI ۱.۹۷ (۱.۰۵-۳.۶۸), p = ۰.۰۳] and unexplained infertility was observed, whereas no association between thrombophilia and female was found. Significantly higher prevalence of prothrombin gene mutation in unexplained infertile women in comparison to that observed in fertile women was observed (۵.۷% vs ۲.۱% p = ۰.۰۴); the prevalence of the other thrombophilia determinants was higher, even if not significantly, in the unexplained infertile group.Conclusion: This study demonstrates the relationship between inherited thrombophilia and recurrent abortion and subsequent infertility, that reflects the part of genetic markers in thrombophilia and it’s influence in women infertility, and explains the reason of IVF procedure failure.

Keywords:

thrombophilia , proteins , infertility , genetic marker