A new long non-coding RNA in pancreatic cancer

Background and Aim: Pancreatic cancer is the eleventh most common cancer around the world and due to its poor clinical symptoms and prognosis pancreatic cancer impose massive costs on every countries health system, Therefore, we decided to find a novel circulating lncRNA for early prediction of pancreatic cancer. Long non-coding RNAs (lncRNAs) have been recently reported to have roles in the cancer regulation and its cell proliferation. Here, we assessed the expression levels of lncRNA linc۰۰۰۹۲ in patients with pancreatic cancer compared with healthy individuals.Methods: In this study, the RNA levels of lncRNA linc۰۰۰۹۲ were investigated in ۳۰ patients with pancreatic cancer and ۳۰ healthy subjects using a qPCR method.Results: The expression level of lncRNA linc۰۰۰۹۲ was strikingly increased in patients with pancreatic cancer compared to healthy subjects. In addition, some notable correlations were found between lncRNA expression levels and demographic data of patients with pancreatic cancer.Conclusion: these data indicate the function of this lncRNA in the glycolysis system and its relation with pancreatic cancer progression which may be a potential biomarker for pancreatic cancer. Although, additional studies are needed to explore the specific mechanism of this lncRNA in the pathogenesis of pancreatic cancer.

Keywords:

long non coding RNAs , linc۰۰۰۹۲ , pancreatic cancer , biomarker