روش های درمانی مبتنی برنقش و متابولیسم سلول های بنیادی سرطان
Publish place: New Cellular Biotechnology - Molecular، Vol: 11، Issue: 41
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: Persian
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شناسه ملی سند علمی:
JR_NCMBJ-11-41_007
تاریخ نمایه سازی: 14 اردیبهشت 1400
Abstract:
سلول های بنیادی سرطانی که سلول های آغازکننده تومور هم شناخته می شوند جمعیت کوچکی از سلول های سرطانی می باشند که توانایی تجدید خود و تمایز به سلول های بنیادی نرمال را دارند. مقاومت بالای سلول های بنیادی سرطانی نسبت به درمان های رایج از قبیل رادیوتراپی و شیمی درمانی یکی ازمشکلات اساسی در نابودی سرطان و عود مجدد می باشد. سلول های بنیادی سرطانی موجود در ریز محیط تومورها از طریق تقسیم نابرابر باعث تشکیل سلول های توموری جدید با خصوصیات متفاوت از نظر ژنتیکی و متابولیتی خواهد شد. بنابراین درمانهایی که مبتنی بر کنترل تکثیر و تمایز سلولهای بنیادی سرطانی باشد را بایدجستجو کرد. در این مقاله مروری ، بر بررسی فنوتیب و متابولیسم سلولهای بنیادی سرطانی پرداخته شده و روشهای درمانی مبتنی برکنترل متابولیسم جهت حذف سلولهای بنیادی سرطانی در ریزمحیط تومور بیان شده است.
Keywords:
Authors
سحر داوری
Department of Microbiology, Bonab Branch, Islamic Azad University, Bonab, Iran
بهناز ولی پور
Applied Pharmaceutical Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
راحله فرحزادی
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
شهرام پوررسول
Department of Microbiology, Bonab Branch, Islamic Azad University, Bonab, Iran
سید منصور ال طاها
Department of Microbiology, Bonab Branch, Islamic Azad University, Bonab, Iran
زهرا حجتی
Department of Microbiology, Bonab Branch, Islamic Azad University, Bonab, Iran
سید هادی چاوشی
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
حجت الله نوزاد چروده
Applied Pharmaceutical Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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