Assessments of Serum ۲۵-Hydroxy Cholecalciferol Levels in Neonates with Physiological Jaundice Candidate for Phototherapy

Background In newborns, jaundice is the most common ailment that necessitates medical treatment and hospital readmission. The aim of this study was to evaluate vitamin D۳ status and investigate the role of phototherapy in the treatment of jaundice and the improvement of vitamin D۳ status in neonates with physiological jaundice. Materials and Methods: This prospective research included ۵۰ full-term neonates with physiological hyperbilirubinemia who were phototherapy candidates. They came from Egypt's Qena University Hospitals' Neonatal Intensive Care Units. Colorimetric assays of albumin and ionized calcium, as well as daily serum bilirubin and an ELISA assay of vitamin D۳ were performed on the included cases before and ۵ days after phototherapy, in addition to clinical assessments. Results: The findings revealed a high prevalence of vitamin D۳ deficiency (۹۶.۷%), and a lower frequency of optimal and insufficient vitamin D۳ status (۳.۳%) with lack of optimal vitamin D۳ status among cases. Post-phototherapy total, direct, and indirect bilirubin levels were significantly lower than pre-therapy levels, with substantial improvement in vitamin D۳ status (p <۰.۰۵ for all). Furthermore, both serum total bilirubin (r=-۰.۷۰۳, p <۰.۰۰۱) and serum indirect bilirubin (r=-۰.۷۱۰, p <۰.۰۰۱) had significantly negative associations with vitamin D۳ serum levels. Conclusion Without vitamin D۳ supplementation, neonates with low vitamin D and physiological jaundice who were received phototherapy had considerably improved vitamin D status ۵ days later.

Keywords:

Egypt , Neonatal hyperbilirubinemia , Physiological jaundice , Vitamin D۳