Is Vitamin C or HAT Therapy Effective in Treating Sepsis? A Mini Review
Publish place: Critical Comments in Biomedicine، Vol: 1، Issue: 2
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_CCB-1-2_007
تاریخ نمایه سازی: 29 اردیبهشت 1400
Abstract:
ABSTRACT Background: One of the most common causes of mortality in critical patients admitted to the intensive care unit (ICU) is sepsis. In recent years, the administration of high doses of vitamin C and HAT (hydrocortisone, ascorbic acid and thiamine) therapy has attracted much attention in patients with sepsis. Objectives: The current article reviews the beneficial effects of HAT therapy in light of research conducted in this area. Methods: A general search for electronic databases was developed. The human studies of the influence of HAT therapy in critically ill patients were evaluated. Results: The results indicated that HAT therapy may improve clinical outcome in septic patients; however, widespread use of these therapeutic approaches in sepsis requires large clinical trials in order to more confidently recommend this therapeutic approach in septic patients admitted to intensive care units. Conclusions: HAT therapy may improve clinical outcome in septic critically ill patients.
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Authors
Kiumarth Amini
Student Research Committee, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Adeleh Sahebnasagh
Clinical Research Center, Department of Internal Medicine, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
Mojtaba Mojtahedzadeh
Faculty of Pharmacy, and Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Tehran, Iran
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