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Effect of chemotherapy on sperm DNA fragmentation

Publish place: Personalized Medicine Journal، Vol: 5، Issue: 18
Publish Year: 1399
Type: Journal paper
Language: English
View: 242

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Link to this Paper:
https://civilica.com/doc/1219543

Document National Code:

JR_PMJ-5-18_001

Index date: 26 May 2021

Effect of chemotherapy on sperm DNA fragmentation abstract

Chemotherapy and radiotherapy adversely affect spermatogenesis, a consequence that is particularly relevant to young men who have yet to establish families. The harmful effects of chemotherapy on spermatogenesis are variable, depending on the type and dosage of chemotherapeutic agents used. The current study assessed the effect of cancer therapy on sperm DNA fragmentation by Comet assay. Sperm DNA fragmentation was evaluated in cured cancer patients. The results showed a significant relationship between chemotherapy and double-stranded and single-stranded sperm DNA fragmentation.    

Effect of chemotherapy on sperm DNA fragmentation Keywords:

Sperm DNA Fragmentation , chemotherapy , infertility , Cancer

Effect of chemotherapy on sperm DNA fragmentation authors

Sadegh Sadegh Shojaei Baghini

Plant Biotechnology, Agriculture Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran.

Ramadhan Ibrahim

Fish Recourses and Aquatic Animals Department, College of Agriculture Salahaddin University, Erbil, Iraq

Hosein Ahmadi

Department of Medical genetic, national Institute for genetic Engineering and Biotechnology, Tehran, Iran

Mona Nadi

Personalized Medicine Research Center of AmitisGen, Tehran, Iran