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Relationship between recurrence pregnancy loss and microRNA expression

Publish place: Personalized Medicine Journal، Vol: 5، Issue: 18
Publish Year: 1399
Type: Journal paper
Language: English
View: 198

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Link to this Paper:
https://civilica.com/doc/1219545

Document National Code:

JR_PMJ-5-18_003

Index date: 26 May 2021

Relationship between recurrence pregnancy loss and microRNA expression abstract

The miRNAs produced predominantly in the placenta are probably involved in placental differentiation and maintenance of pregnancy. One of the important functions of miR-126 is its involvement in angiogenesis by enhancing the expression of VEGF. Abnormalities of placental vasculature may result in several gestational complications, including pregnancy loss. The current study compared the expression of miR-126 in the plasma of women with recurrent miscarriages and women with healthy pregnancies by Realtime qRT-PCR. The results indicated that the expression difference of miR-21 between the pregnant patients and the controls was statistically significant (p =0.002). This microRNA can be used as a biomarker in diagnosis and progression.

Relationship between recurrence pregnancy loss and microRNA expression Keywords:

MicroRNA , Recurrent Pregnancy Loss , Gene expression , Realtime qRT-PCR

Relationship between recurrence pregnancy loss and microRNA expression authors

Hadi Yari

Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran.

kazhaleh Mohammadi

Researcher and lecture assistant at the Medical Laboratory Science Department, Knowledge University, Kurdistan Region, Erbil, Iraq

Mohammad Ali Keshavarz Shahbaz

Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran

Vahid Reza Esfahani

Personalized Medicine Research Center of AmitisGen, Tehran, Iran