Investigation of Chemical Composition of Oriental plane (Platanus orientalis L.) Hydrosol and its Effects on Tissue Damage Markers and Plasma Enzymes in Short-term Consumption
Publish place: Trends in Pharmaceutical Sciences، Vol: 6، Issue: 4
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 8 خرداد 1400
Abstract:
Oriental plane hydrosol (distillate), as a remedy for weight gain and asthma treatment is popular in ethnomedicine. Phytochemicals of medicinal plants could have side effects or serious damages. In this study, the oriental plane hydrosol was prepared by steam distillation. Also, tree oriental plane hydrosol samples from different companies were purchased from herbal market to compare the constituents. The phytochemicals in hexane and chloroform extracts of the hydrosols were identified by GC-MS analysis. In order to investigate subacute toxicity, the hydrosol was given to groups of ۶ of male mice at doses of ۱۰, ۵۰, ۱۰۰, ۳۰۰ or ۵۰۰ µl/ mouse/ twice a day by gavage for ۱۴ consecutive days (subacute toxicity) or just for one day (acute toxicity). Serologic and pathologic samples were prepared. Chloroform extracts contained mostly (Z) -۳-hexenol, thymol, carvacrol, camphor and the main constituents of hexane extracts include decane, dodecane and hexadecane. The results showed lack of serologic toxicity in subacute consumption of the hydrosol. In acute toxicity study, the levels of ALT, LDH, and BUN increased significantly. Other enzymes did not change significantly in compare to the control group. No significant pathologic damage was seen in heart or lung tissues, but the liver and kidney showed mild inflammation in acute toxicity study and inflammation in subacute toxicity studies. Determination of compounds which are responsible for the observed effects and especially safety of this hydrosol consumption for the longer periods can prevent side effects or possible toxicities.
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Authors
Reza Heidari
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Akbar Raeisi
Student research committee, School of pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Ardalan Pasdaran
Medicinal Plants Processing Research Center, Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Azadeh Hamedi
Department of Pharmacognosy, School of Pharmacy, Shiraz Unicersity of Medical Sciences, Shiraz, Iran
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