Risk Factors for Ulcerative Colitis in Shahrekord, Iran: A Case-Control Study

Background and aims: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) whichinvolves the rectum and colonic mucosa, and is often constantly expanding. Few data are available onrisk factors in Chaharmahal and Bakhtiari province. Therefore, the aim of this study was to investigatethe association between potential risk factors and UC in Shahrekord.Methods: A case-control study was conducted on patients diagnosed with UC. Overall, ۲۷ new casesof UC and ۵۴ healthy controls in the age range of ۲۰–۸۰ years were studied. Participants were recruitedfrom Pathologic Centers in Shahrekord in ۲۰۱۸. Chi-square test and t test and were used. Logisticregression model was employed to analyze the association between risk factors and UC disease.Results: The mean age at diagnosis was ۴۱.۷۴ years (SD: ۷.۱۶ years) and ۴۴.۹۴ years (SD: ۶.۶۷years) for case and control subjects, respectively. Moreover, univariate and multiple odds ratio (OR)showed that there was no significant association between UC and any of the risk factors includinggender, marital status, education, diastolic blood pressure, history of diabetes, history of hypertension,permanent use of piped water, night shift work, history of thyroid diseases, depression, history of fattyliver disease, history of kidney stones, and sleep time and wake-up time in the morning.Conclusion: Generally, no significant association was observed between UC and the variables in thepresent study. Thus, further studies with larger sample size are necessary to better understand the otherrisk factors and environmental determinants of UC.

Keywords:

Ulcerative Colitis , Inflammatory bowel disease , Risk Factors , Case-control