Association of the KCNJ۱۱ rs۵۲۱۹ E۲۳K polymorphism with Type ۲ Diabetes

Diabetes mellitus (DM) is a major public health issue in worldwide. Type ۲ diabetes does not have a clear pattern of inheritance, although many affected individuals have at least one close family member, such as a parent or sibling, with the disease. The KCNJ۱۱ gene is a member of the potassium channel gene family. polymorphisms  in KCNJ۱۱  result  in  neonatal  diabetes and congenital hyper-insulinaemia, wherein the E۲۳K (rs۵۲۱۹) polymorphism is linked with diabetes susceptibility where the K allele plays an important role in insulin secretion. In this study, we evaluate the frequency of these polymorphisms in a Kurdish population of ۸۵ with type ۲ diabetes. E۲۳K polymorphism of KCNJ۱۱ gene was genotyped by PCR-RFLP method. heterozygous carriers for AG are more in non‑diabetic patients (P = ۰.۰۳۴).

Keywords:

Diabetes Mellitus , single nucleotide polymorphism , PCR-RFLP , biomarker