Comparison of the Therapeutic Effects of Nano-essence of Artemisia sieberi with the Terbinafine 1% in Animal Model Dermatophytosis

Background and aims: One of the most important world wide zoonotic infection is dermatophytosis which caused by dermatophytes fungi. Dermatophytosis treatment minimizing the time course of the infection and the potential of spread to other animals and humans. The aim of  this study is to use the Artemisia sieberi nano-essence to treat dermatophytosis caused by Microsporum canis under experimental conditions in guinea pigs. Methods: In this study guinea pigs randomly divided to 7 groups; negative control, positive control, terbinafine hydrochloride 1% and 4 different nano-essence concentrations treatment. 5 day after Microsporum canis suspension inoculation to abraded skin, treatment program for every nano-essence dilutions and terbinafine was started every 12 hours for 40 days. Results: Comparison of all nano-essence and terbinafine treatment groups on various days till 4oth day revealed no significant differences. Three consecutive culture results for all animals was negative on days 33, 40 and 50 in nano-essence groups but 16% of terbinafine groups was positive in fungi culture on day 33. Conclusions: The results showed the nano-essence treatment groups showed improved clinical symptoms faster than the terbinafine treatment group over a shorter treatment period.

Comparison of the Therapeutic Effects of Nano-essence of Artemisia sieberi with the Terbinafine 1% in Animal Model Dermatophytosis Keywords:

Guinea Pig , Terbinafine , Artemisia sieberi , Microsporum canis , Nano-essence