Evaluation of serum concentration of AFP marker in toxoplasmosis pregnant women with high level of IgG and IgM toxoplasma antibody by ELISA assay in a population of Tehran, Iran

Background and aims: Toxoplasmosis is a parasitic disease which may cause some laboratory symptoms in infected individuals. One of the main ways of transmition this organism is placenta to fetus pathway. If this transmission occurs in the ۳th month of pregnancy, the abortion, central nerve system and ocular disorder will happen. Because of this issue, the precise technique for detection of Toxoplasma Antibody such as IgG and IgM is important, that contains ELISA to detect Toxoplasma Antibody such as IgG and IgM and AFP. Methods: This was a cross sectional study. In this study, the main sample was serum that was randomly collected from ۲۵۵ pregnant women infected with toxoplasma Gondi in Avesina center. Then, It was detected the serum concentration of AFP in toxoplasmosis pregnant women with high level of IgG and IgM toxoplasma antibody by ELISA assay. Results: The results of this survey showed that the infection in these pregnant women by toxoplasma gondii was occurred and ۱۳% of them (۱۳% of ۲۵۵ infected mothers) had high levels of AFP in their serum. The statistical analyses was done by SPSS consisted of t-test, case number, comparative study, and Q-Q plot evaluations. Conclusions: In some pregnant women with high level of IgG and IgM toxoplasma antibody was observed in high levels of AFP in their serum and this index correlates with NTD in their fetus.

Keywords:

Toxoplasma gondii , ELISA , IgG antibody , IgM antibody , AFP , Iran