The purpose of this study is theoretical and methodological substantiation, deepening of conceptual provisions and development of scientific and practical recommendations for the formation of an integrated sector of national security and defense based on the principles of national resilience. The relevance of this study is due to the need to build national resilience to address the main problems of national security of Ukraine. The main components of national security and resilience development of the country on the basis of global indices are considered, the main patterns and key problems of national security of Ukraine are highlighted. Studies have found, which is a condition for providing national security is the formation of an appropriate level of internal resilience of the state, the basis of which is economic resilience, the rule of law, modern infrastructure, education and medicine. It is established that Ukraine is characterized by a low level of management in the public administration system, a high level of corruption, low efficiency of government decisions, non-compliance with current legislation in various spheres of life. it is proved that it is necessary for the formation of an integral sector of national security and defense a balanced combination of the capabilities of the main elements of the national security system and the objects of national resilience. Priority areas for building national resilience have been identified for Ukraine: creation of a multilevel risk assessment system; improving strategic planning, analysis and crisis management; developing the resilience potential of local communities and regions. A formalized model of an integrated national security system is proposed, based on the principles of resilience of regional security parameters of all regions of Ukraine and a resource-oriented approach to the transition of the existing state of regional security to the desired state.