The Relationship Between Polymorphic Fibroblast Growth Factor Receptor (FGFR) Gene and Breast Cancer Risk

Background: Genetic factors associated with cancer have been widelyinvestigated and several polymorphisms have been connected with breast cancer.Breast cancer (BC) can be considered one of the most popular reasons of deathamong women. BC, likewise, is the second cause of death in Iran. The presentresearch aims at determining the frequency of the fibroblast growth factor receptor(FGFR) gene polymorphism in patients with breast cancer.Methods: The FGFR family is one of the tyrosine kinase receptors containing۴ members, whose pathway is activated in many tumors. We assessed, for thefirst time, these polymorphisms and their consequences on the breast cancer riskassociation in an Iranian sporadic population-based case-control study including۱۲۶ patients with breast cancer and ۱۶۰ controls using a PCR-RFLP-based assay.Results: The analyses of the experimental and control groups indicated thathomozygote genotype FGFR۴ Gly/Gly has the highest frequency in experimentaland control groups (۳۰.۴% and ۱۸.۹%). The main genotype FGFR۴ Gly/Glyrisk factors in our population were: ArgGly /GlyGly, OR = ۲.۳۵۹, ۹۵% CI =۰.۲۰۸ - ۴.۶۲۱, P = ۰.۰۰۱; ArgArg /ArgGly, OR = ۰.۴۱۲, ۹۵% CI = ۰.۰۸۲ - ۰.۵۴۷, P =۰.۰۷۸, ArgArg /GlyGly, OR = ۰.۰۷۶, ۹۵% CI = ۰.۰۳۰ - ۰.۱۸۹, P = ۰.۲۶.Conclusions: A significant association was observed between breast cancerrisk and FGFR۴ GlyGly and ArgGly polymorphism.

Keywords:

BstNI , PCR-RFLP , FGFR۴ gene , polymorphism , breast cancer