Synthesis and Characterization of Host Guest Inclusion Complexes of Cyclodextrin Molecules with Theophylline by Diverse Methodologies
Publish place: Italian Journal of Science & Engineering، Vol: 4، Issue: 1
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJSE-4-1_009
تاریخ نمایه سازی: 25 تیر 1400
Abstract:
Steady host–guest inclusion complexes have been produced with medicinally important guest molecule theophylline within aqueous α-Cyclodextrin and HP-β-Cyclodextrin. α-and HP-β-Cyclodextrins have been established with favorable structural features for inclusion with Theophylline which include diversified applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing, pesticides, foodstuffs etc. Theophylline is one of the most widely accepted drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, even if it has been used clinically for many years. With both α and HP-β-Cyclodextrins it is found that ۱:۱ hosts-guest inclusion complexes are formed with the guest molecule theophylline. The construction and quality of the inclusion complexes have been characterized by using conductivity measurement, surface tension study, and Job’s method. The inclusion phenomenon has been confirmed by FTIR spectroscopy, proton NMR study. Association constants and thermodynamic parameters have been evaluated for the created inclusion complexes by ultraviolet spectroscopy.
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Authors
Ashutosh Dutta
Department of Technology, Uttar Banga Krishi Viswavidyalaya, Coochbehar-۷۳۶۱۶۵, India
Niloy Roy
Department of Chemistry, University of North Bengal, Darjeeling-۷۳۴۰۱۳, India
Koyeli Das
Department of Chemistry, University of North Bengal, Darjeeling-۷۳۴۰۱۳, India
Debadrita Roy
Department of Chemistry, University of North Bengal, Darjeeling-۷۳۴۰۱۳, India
Raja Ghosh
Department of Chemistry, University of North Bengal, Darjeeling-۷۳۴۰۱۳, India
Mahendra Nath Roy
Department of Chemistry, University of North Bengal, Darjeeling-۷۳۴۰۱۳, India