Risk Factors of Mortality among Hospitalized COVID-۱۹ Patients in A Large University Hospital in Tehran, Iran
Publish place: Infection Epidemiology and Microbiology، Vol: 7، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IEM-7-2_005
تاریخ نمایه سازی: 28 تیر 1400
Abstract:
Backgrounds: Coronavirus disease ۲۰۱۹ (COVID-۱۹) pandemic is considered as a global health challenge, and Iran is among the top ten countries with the highest mortality rate. This study aimed to analyze epidemiological, clinical, and laboratory features of hospitalized SARS-CoV-۲ infected patients and identify the risk factors of mortality among them to facilitate the prioritization of resources and vaccine allocation in the population using data available in a large university hospital in Tehran, Iran.
Materials & Methods: From February ۲۰ to May ۱۴, ۲۰۲۰, a total of ۶۸۴ COVID-۱۹ confirmed cases were admitted to Imam Hossein University hospital in Tehran and enrolled in this retrospective observational study.
Findings: The mean age of the participants was ۵۹.۴۸±۱۶.۶۵ years, and ۵۵.۸% were male. Compared to survivors, non-survivors (n=۱۲۷, ۱۸.۵۷%) were older (۶۹.۰۹±۱۴.۱۶ vs. ۵۷.۲۹±۱۶.۴۰), had higher average number of comorbidities, and more frequently suffered from dyspnea, convulsion, loss of consciousness (LOC), tachycardia, tachypnea, and hypoxia. They also had higher levels of leukocytes, neutrophil count, C-reactive protein (CRP), creatine phosphokinase (CPK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), international normalized ratio (INR), prothrombin time (PT), partial thromboplastin time (PTT), urea, and serum creatinine (p<.۰۵). Serum potassium (K), lymphocyte count, hemoglobin, HCO۳, and serum sodium (Na) were significantly lower in non-survivors. Multivariable logistic regression analysis results revealed that nine variables were positively associated with mortality.
Conclusion: Among COVID-۱۹ patients admitted to the hospital, having more than two or three comorbidities, loss of consciousness, SpO۲ < ۹۰%, increased CRP, CPK, urea, and serum potassium, were associated with mortality.
Keywords:
Authors
Mehrdad Haghighi
Department of Infectious Diseases, Imam Hossein Teaching and Medical Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein Hatami
Department of Public Health, School of Public Health and Safety and Environmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shayan Aryannezhad
School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Negar Delbari
School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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