Metastatic and pathophysiological characteristics of breast cancer with emphasis on hereditary factors
Publish place: Central Asian Journal of Medical and Pharmaceutical Sciences Innovation، Vol: 1، Issue: 3
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_CAJMPSI-1-3_001
تاریخ نمایه سازی: 9 مرداد 1400
Abstract:
Breast cancer is the most common type of cancer among women and the second leading cause of deaths after lung cancer. Each year, more than ۱۸۰,۰۰۰ new cases of breast cancer are diagnosed in the United States. The risk of breast cancer is low before the age of ۳۵, but the high prevalence of this type of cancer is diagnosed after the age of ۳۵. The risk of developing breast cancer in a woman's lifetime is about ۱۰% and ۵-۱۰% with a familiar genetic basis. The accumulation of breast and ovarian cancers in certain families indicates that genetic variations are involved in developing these types of cancers. In ۱۹۹۴, two genes were identified to be linked to familial breast cancers. Gene variations in these two genes (BRCA۱ and BRCA۲) are found in most familial breast cancers, and variations in several other genes may also be involved in this cancer. The molecular functions of BRCA۱ and BRCA۲ are still unclear, although they could be involved in repairing damaged DNA or regulating the transcription of hormone-responsive genes. Mutations in these genes are predominantly autosomally transmitted by variable penetration. Women with BRCA۱ variations are up to ۵۰ percent more susceptible to breast cancer pending their lifetime. However, there are some other genes in which the variation may result in breast cancer occurrence. In this paper, we assessed some features of breast cancer to focus on hereditary aspects.
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Authors
Azita Faramarzi
Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Masoumeh Golestan Jahromi
Department of Advanced Medical Science & amp, Technologies, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
Sareh Ashourzadeh
Afzalipour clinical center for infertility, Kerman University of Medical Sciences, Kerman, Iran
Nasrin Jalilian
Department of Obstetrics and Gynecology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
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